Non-malignant Blood Disorders Scientists

Dr. Sara Israels, MD FRCPC

Our platelet research laboratory studies basic mechanisms of platelet function and investigates patients with inherited platelet function abnormalities, in conjunction with the clinical Haemostasis Laboratory. Our projects include:

1) Studies of patients with inherited platelet function disorders, with a particular interest the ultrastructure of platelets as defined by electron microscopy.

2) Development of a national registry of patients with inherited platelet disorders, an opportunity to improve our understanding of these rare conditions, aid in their diagnosis, and evaluate treatment options.

3) Initiatives to standardize laboratory testing of platelet function and evaluate new methods for testing that will be clinically relevant.

4) Investigating the role of CD63, a member of the tetraspanin superfamily present on platelet dense granule and lysosomal granule membranes, and expressed on the platelet surface following activation, where it associates with the platelet integrin αIIbβ3, and with the contractile platelet cytoskeleton. It plays a role in platelet spreading on adhesive surfaces. Understanding the role of CD63 has implications beyond platelet function, as it, and similar molecules, may be involved in tumour cell migration and metastases.

Contact information:

Department of Pediatric Hematology and Oncology
675 McDermot Ave
Winnipeg, Mb
R3E 0V9

PubMed Links

Dr. Ryan Zarychanski MD MSc FRCPC

Dr. Ryan Zarychanski is an Assistant Professor and Clinician-Scientist at the University of Manitoba in the Department of Medicine, Sections of Critical Care and of Hematology/Medical Oncology. Following subspecialty fellowships Hematology and Critical Care Medicine, he obtained a Masters degree in Epidemiology and Community Medicine, and undertook a research fellowship at the University of Ottawa. Dr. Zarychanski’s research focuses on the hematologic aspects of critical illness. Major programs of research include evaluating efficacy and safety of heparin and IVIG in patients with septic shock. Recent research includes evaluating processes of care in massive transfusion and investigating blood products and blood conservation in the critically ill.

Dr. Zarychanski is the Director of Knowledge Synthesis at the Centre for Healthcare Innovation in Winnipeg, Manitoba and was awarded the Lyonel G. Israels Professorship in Hematology from the University of Manitoba in 2016 and the Canadian Institute of Health Research (CIHR) New Investigator Award in 2014.

Contact information

2056-675 McDermot Ave
Winnipeg, MB R3E 0V9

Pubmed Links