Research Interests:

My research focuses on the study of gene expression during human breast tumorigenesis. It is indeed believed that the knowledge of the genetic changes that occur during the transition between different pre-neoplastic and pre-invasive breast lesions and that manifest themselves as alteration of gene expression, will allow the identification of targets for new preventive and curative strategies.

Selected Publications:

1. Chooniedass-Kothari S, Hamedani MK, Troup S, Hube F, Leygue E. The steroid receptor RNA activator protein is expressed in breast tumor tissues. Int J Cancer. 2006 Feb 15;118(4):1054-9. PMID: 16152589
2. Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett. 2004 May 21;566(1-3):43-7. PMID: 15147866
3. Guan XF, Hamedani MK, Adeyinka A, Walker C, Kemp A, Murphy LC, Watson PH, Leygue E. Relationship between mammaglobin expression and estrogen receptor status in breast tumors. Endocrine. 2003 Aug;21(3):245-50. PMID: 14515009
4. Emberley E, Huang GJ, Hamedani MK, Czosnek A, Ali D, Grolla A, Lu B, Watson, PH, Murphy LC, Leygue E. Identification of new human coding steroid receptor RNA activator isoforms. Biochem Biophys Res Commun. 2003 Feb 7;301(2):509-15. PMID: 12565891 
5. Miksicek RJ, Myal Y, Watson PH, Walker C, Murphy LC, Leygue E. Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium. Cancer Res. 2002 May 15;62(10):2736-40. PMID: 12019145 [PubMed - indexed for MEDLINE]
6. Leygue E, Dotzlaw H, Watson PH, Murphy LC. Expression of the steroid receptor RNA activator in human breast tumors. Cancer Res. 1999 Sep 1;59(17):4190-3. PMID: 10485452